Horn E, Lach B, Lapierre Y, Hrdina P
Department of Psychiatry, Royal Ottawa Hospital, Ont., Canada.
Am J Psychiatry. 1988 May;145(5):617-20. doi: 10.1176/ajp.145.5.617.
The pathogenesis of the neuroleptic malignant syndrome is currently unclear, and no specific morphological abnormalities in the CNS of victims of neuroleptic malignant syndrome have been described. The authors report a case of neuroleptic malignant syndrome with recent foci of necrosis in the anterior and lateral hypothalamic nuclei. They discuss the role of tricyclic antidepressants, monoamine oxidase inhibitors, and neuroleptics in the development of this syndrome. They conclude that although the pathogenesis of the neuroleptic malignant syndrome is still not clear, necrosis of the hypothalamic nuclei may be pathognomonic for this syndrome.
抗精神病药恶性综合征的发病机制目前尚不清楚，且尚未见有关抗精神病药恶性综合征患者中枢神经系统特定形态学异常的描述。作者报告了1例抗精神病药恶性综合征患者，其下丘脑前核和外侧核有近期坏死灶。他们讨论了三环类抗抑郁药、单胺氧化酶抑制剂及抗精神病药在该综合征发生过程中的作用。他们得出结论，尽管抗精神病药恶性综合征的发病机制仍不清楚，但下丘脑核坏死可能是该综合征的特征性表现。
