Gabellini A S, Pezzoli A, De Massis P, Casadei G, Grillo A, Sacquegna T
Servizio di Neurologia, Ospedale Maggiore, Bologna.
Ital J Neurol Sci. 1994 Sep;15(6):293-5. doi: 10.1007/BF02339239.
Neuroleptic malignant syndrome (NMS) has been recently described following therapy with non strictly neuroleptic drugs that alter dopaminergic function, such as sulpiride and metoclopramide, and might occur more easily in patients with functional or organic brain disorders. We observed an AIDS patient who suffered from NMS following treatment with clotiapine for insomnia and agitation. Two months later, he presented with a similar syndrome following antiemetic treatment with alizapride. On both occasions, the symptoms completely regressed after the administration of dopaminergic and muscle relaxant drugs. The patient died of pneumonia one month after the last episode. The present paper describes the clinical and pathological findings.
最近有报道称，在使用并非严格意义上的抗精神病药物（如舒必利和甲氧氯普胺）进行治疗后，会引发改变多巴胺能功能的神经阻滞剂恶性综合征（NMS），且该综合征在患有功能性或器质性脑部疾病的患者中可能更容易发生。我们观察到一名艾滋病患者，在用氯氮平治疗失眠和烦躁后患上了NMS。两个月后，他在使用阿立必利进行止吐治疗后又出现了类似综合征。两次发病时，在给予多巴胺能药物和肌肉松弛剂后症状均完全消退。该患者在最后一次发作后一个月死于肺炎。本文描述了临床和病理检查结果。
