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便秘手术:系统评价和实践建议:结果 IV:直肠阴道加强术。

Surgery for constipation: systematic review and practice recommendations: Results IV: Recto-vaginal reinforcement procedures.

机构信息

National Bowel Research Centre, Blizard Institute, Queen Mary University of London, London, UK.

Health Economics, University of Warwick, Coventry, UK.

出版信息

Colorectal Dis. 2017 Sep;19 Suppl 3:73-91. doi: 10.1111/codi.13781.

Abstract

AIM

To assess the outcomes of recto-vaginal reinforcement procedures in adults with chronic constipation.

METHOD

Standardised methods and reporting of benefits and harms were used for all CapaCiTY reviews that closely adhered to PRISMA 2016 guidance. Main conclusions were presented as summary evidence statements with a summative Oxford Centre for Evidence-Based Medicine (2009) level.

RESULTS

Forty-three articles were identified, providing data on outcomes in 3346 patients. Average length of procedures ranged between 20 and 169 min, and length of stay between 1 and 15 days. Complications typically occurred after 7-17% of procedures (range 0-61%). Post-operative bleeding was uncommon (0-4%) as well as haematoma or sepsis (0-2%). Fistulation did not occur in most studies. Two procedure-related deaths were observed for 3209 patients. Although inconsistent, 78% of patients reported a satisfactory or good outcome, with 30-50% experiencing reduced symptoms of straining, incomplete emptying or reduced vaginal digitation. About 17% of patients developed anatomical recurrence. Considering measures of harm and global satisfaction rating scales, there was insufficient evidence to prefer one type of procedure over another. There was no evidence to support better outcomes based on selection of patients with a particular size or grade of rectocoele.

CONCLUSION

Evidence supporting recto-vaginal reinforcement procedures is currently derived from observational studies and comparisons, with only one high quality study. Large trials are needed to inform future clinical decision making.

摘要

目的

评估直肠阴道加强术治疗成人慢性便秘的疗效。

方法

所有 CapaCiTY 综述均采用标准化方法和利益与危害报告,严格遵循 PRISMA 2016 指南。主要结论以汇总证据陈述的形式呈现,并采用牛津循证医学中心(2009 年)的总结性评估级别。

结果

共确定了 43 篇文章,提供了 3346 例患者的结局数据。手术平均时长在 20-169 分钟之间,住院时长在 1-15 天之间。并发症通常发生在术后 7-17%(范围 0-61%)的病例中。术后出血(0-4%)、血肿或脓毒症(0-2%)均不常见。大多数研究中未发生瘘管。3209 例患者中有 2 例与手术相关的死亡。尽管结果不一致,但 78%的患者报告治疗效果满意或良好,30-50%的患者排便费力、排空不完全或阴道触诊感减轻的症状得到缓解。约 17%的患者出现解剖学复发。考虑到危害和总体满意度评分测量指标,目前尚无充分证据表明某种手术类型优于另一种。没有证据表明根据特定直肠阴道膨出大小或程度选择患者可以获得更好的结局。

结论

目前支持直肠阴道加强术的证据来自观察性研究和比较研究,仅有一项高质量研究。需要开展大型试验来为未来的临床决策提供信息。

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