National Bowel Research Centre, Blizard Institute, Queen Mary University London, London, UK.
University of Warwick, Coventry, UK.
Colorectal Dis. 2017 Sep;19 Suppl 3:37-48. doi: 10.1111/codi.13773.
To assess the outcomes of rectal suspension procedures (forms of rectopexy) in adults with chronic constipation.
Standardised methods and reporting of benefits and harms were used for all CapaCiTY reviews that closely adhered to PRISMA 2016 guidance. Main conclusions were presented as summary evidence statements with a summative Oxford Centre for Evidence-Based Medicine (2009) level.
Eighteen articles were identified, providing data on outcomes in 1238 patients. All studies reported only on laparoscopic approaches. Length of procedures ranged between 1.5 to 3.5 h, and length of stay between 4 to 5 days. Data on harms were inconsistently reported and heterogeneous, making estimates of harm tentative and imprecise. Morbidity rates ranged between 5-15%, with mesh complications accounting for 0.5% of patients overall. No mortality was reported after any procedures in a total of 1044 patients. Although inconsistently reported, good or satisfactory outcome occurred in 83% (74-91%) of patients; 86% (20-97%) of patients reported improvements in constipation after laparoscopic ventral mesh rectopexy (LVMR). About 2-7% of patients developed anatomical recurrence. Patient selection was inconsistently documented. As most common indication, high grade rectal intussusception was corrected in 80-100% of cases after robotic or LVMR. Healing of prolapse-associated solitary rectal ulcer syndrome occurred in around 80% of patients after LVMR.
Evidence supporting rectal suspension procedures is currently derived from poor quality studies. Methodologically robust trials are needed to inform future clinical decision making.
评估直肠悬吊术(直肠固定术的一种形式)在慢性便秘成人患者中的疗效。
所有 CapaCiTY 综述均采用标准化的方法和利益与危害的报告,严格遵循 PRISMA 2016 指南。主要结论以总结证据陈述的形式呈现,并采用牛津循证医学中心(2009 年)的总结性评估级别。
共确定了 18 篇文章,提供了 1238 例患者结局数据。所有研究均仅报告腹腔镜方法。手术时间在 1.5 至 3.5 小时之间,住院时间在 4 至 5 天之间。危害数据报告不一致且存在异质性,使得危害估计不确定且不精确。发病率在 5-15%之间,总体上,网片并发症占患者的 0.5%。在总共 1044 例患者中,无任何手术的死亡报告。尽管报告不一致,但 83%(74-91%)的患者出现良好或满意的结局;86%(20-97%)的腹腔镜腹侧网片直肠固定术(LVMR)患者报告便秘改善。约 2-7%的患者出现解剖学复发。患者选择记录不一致。最常见的适应证是高位直肠内套叠,机器人或 LVMR 后 80-100%的病例得到纠正。LVMR 后,脱垂相关孤立性直肠溃疡综合征的愈合率约为 80%。
目前支持直肠悬吊术的证据来自质量较差的研究。需要进行方法学上稳健的试验,为未来的临床决策提供信息。