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[在谷氨酸和γ-氨基丁酸的N-烟酰基衍生物中寻找和研究具有精神活性的生物活性物质]

[Search for and study of biologically active substances with psychotropic activity among the N-nicotinoyl derivatives of glutamic and gamma-aminobutyric acids].

作者信息

Kuz'menko G I, Gotsuliak L E, Gaĭdenko A I, Kazanov A D, Niiaka M F

出版信息

Farmakol Toksikol. 1988 Jan-Feb;51(1):12-4.

PMID:2896131
Abstract

Four new derivatives of glutamic and gamma-aminobutyric acids influencing the central nervous system were produced. By the character of their action they refer to the substances of the sedating tranquilizing type without the myorelaxant component. The drug activity degree depends on its ability to penetrate through cell membranes that is in turn determined by the structure of the compound.

摘要

制备出了四种影响中枢神经系统的谷氨酸和γ-氨基丁酸新衍生物。根据其作用特点,它们属于无肌松成分的镇静安定型物质。药物的活性程度取决于其穿透细胞膜的能力,而这又反过来由化合物的结构所决定。

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