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酵母细胞周期调控基因cdc2的人类同源基因的进化保守性及Cd2定位于10号染色体

Evolutionary conservation of the human homologue of the yeast cell cycle control gene cdc2 and assignment of Cd2 to chromosome 10.

作者信息

Spurr N K, Gough A, Goodfellow P J, Goodfellow P N, Lee M G, Nurse P

机构信息

Human Genetic Resources, Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK.

出版信息

Hum Genet. 1988 Apr;78(4):333-7. doi: 10.1007/BF00291730.

DOI:10.1007/BF00291730
PMID:2896153
Abstract

The human homologue of the fission yeast Schizosaccharomyces pombe cell cycle control gene cdc2 has been assigned to chromosome 10. DNA hybridization reveals that this gene is highly conserved in vertebrates. The human CDC2 gene probe detects a simple two-allele polymorphism in Taq1-digested DNA.

摘要

粟酒裂殖酵母细胞周期控制基因cdc2的人类同源基因已被定位于10号染色体。DNA杂交显示该基因在脊椎动物中高度保守。人类CDC2基因探针在经Taq1酶切的DNA中检测到一种简单的双等位基因多态性。

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1
Evolutionary conservation of the human homologue of the yeast cell cycle control gene cdc2 and assignment of Cd2 to chromosome 10.酵母细胞周期调控基因cdc2的人类同源基因的进化保守性及Cd2定位于10号染色体
Hum Genet. 1988 Apr;78(4):333-7. doi: 10.1007/BF00291730.
2
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2.利用互补作用克隆了裂殖酵母细胞周期控制基因cdc2的一个人类同源基因。
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Cell cycle control genes in fission yeast and mammalian cells.裂殖酵母和哺乳动物细胞中的细胞周期调控基因。
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The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation.裂殖酵母的细胞周期控制基因cdc2+编码一种可能受磷酸化调节的蛋白激酶。
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引用本文的文献

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Complete sequence of human vinculin and assignment of the gene to chromosome 10.人纽蛋白的完整序列及该基因在10号染色体上的定位
Proc Natl Acad Sci U S A. 1990 Aug;87(15):5667-71. doi: 10.1073/pnas.87.15.5667.
2
A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.小鼠10号染色体的遗传连锁图谱：利用单一物种间回交对18个分子标记进行定位
Genetics. 1990 Aug;125(4):855-66. doi: 10.1093/genetics/125.4.855.
3
Regional assignment of the human cell cycle control gene CDC2 to chromosome 10q21 by in situ hybridization.

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