Department of Neurosurgery, Duke University Hospital, Durham, North Carolina.
Oper Neurosurg (Hagerstown). 2018 Jul 1;15(1):1-9. doi: 10.1093/ons/opx180.
Dissecting aneurysms of the intracranial vertebral arteries are rare; however, treatment of these presents multiple challenges, including high risk of rebleeding, development of thromboembolic strokes, and progressive partial thrombosis. Flow diverters, such as Pipeline Endovascular Devices (PEDs; Covidien, Medtronic Inc, Dublin, Ireland), have emerged as a potential treatment option.
To present our experience with patients treated at our institution with PEDs for dissecting distal vertebral artery (V4 segment) aneurysms.
A retrospective search of our prospectively maintained database was performed between January 2014 and December 2016. We queried our database for all patients treated with PED for dissecting aneurysms of the V4 segment. Information was gathered including demographics, the location and morphology of the aneurysm, the clinical presentation, specific form of treatment, complications, antiplatelet medication regimen, and follow-up time.
There were a total of 9 patients with dissecting V4 aneurysms treated with PED during the study period. All were treated initially with an average of 1.2 PEDs. All patients were followed with at least one repeat diagnostic angiogram and there was no residual aneurysm seen in 8 of 9 cases. In those that presented with neurological deficits, there was an average improvement in modified Rankin Scale of 2.85 points.
PED is a safe and effective tool that can be used to treat ruptured dissecting aneurysms of this specific segment of the posterior circulation, but it does require close management of antiplatelet therapy in the setting of subarachnoid hemorrhage and close angiographic follow-up.
颅内椎动脉夹层动脉瘤较为罕见,但此类疾病的治疗极具挑战性,包括再出血风险高、血栓栓塞性中风发展和部分血栓渐进性形成等。血流导向装置(如 Pipeline 血管内装置(PED;Covidien,Medtronic Inc,都柏林,爱尔兰))已成为一种潜在的治疗选择。
介绍我们在机构中使用 PED 治疗颅内椎动脉(V4 段)夹层动脉瘤患者的经验。
我们对 2014 年 1 月至 2016 年 12 月期间前瞻性维护的数据库进行了回顾性搜索。我们在数据库中查询了所有使用 PED 治疗 V4 段夹层动脉瘤的患者。收集的信息包括人口统计学数据、动脉瘤的位置和形态、临床表现、具体治疗方式、并发症、抗血小板药物治疗方案和随访时间。
在研究期间,共有 9 例 V4 段夹层动脉瘤患者接受 PED 治疗。所有患者平均接受 1.2 个 PED 治疗。所有患者均接受至少一次重复诊断性血管造影,9 例患者中有 8 例未见残留动脉瘤。对于出现神经功能缺损的患者,改良 Rankin 量表的平均改善为 2.85 分。
PED 是一种安全有效的工具,可用于治疗后循环这一特定节段的破裂性夹层动脉瘤,但在蛛网膜下腔出血的情况下,需要密切管理抗血小板治疗,并密切进行血管造影随访。