1,2-二肉豆蔻酰-sn-甘油-3-磷酸胆碱（DMPC）可提高卡莫氟的稳定性及抗增殖效果。
1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and antiproliferative effect.
作者信息
Domracheva Ilona, Muhamadejev Ruslan, Petrova Marina, Liepinsh Edvards, Gulbe Anita, Shestakova Irina, Duburs Gunars, Arsenyan Pavel
机构信息
Latvian Institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia.
出版信息
Toxicol Rep. 2015 Jan 27;2:377-383. doi: 10.1016/j.toxrep.2015.01.009. eCollection 2015.
Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for studies was characterized and monitored by H NMR. Antiproliferative activity studies on various tumor cell lines showed considerable increase of Carmofur ability to prevent tumor cell growth, when it is added as a mixture with DMPC. This technique opens a way for Carmofur drug delivery in neutral and basic media.
添加二肉豆蔻酰磷脂酰胆碱（DMPC）可显著抑制卡莫氟在中性磷酸盐缓冲溶液中的降解，并且该药物受pH值的影响变小。通过核磁共振氢谱（H NMR）对添加DMPC以进行研究时在中性pH条件下卡莫氟的稳定性进行了表征和监测。对各种肿瘤细胞系的抗增殖活性研究表明，当卡莫氟与DMPC混合添加时，其预防肿瘤细胞生长的能力显著增强。该技术为卡莫氟在中性和碱性介质中的药物递送开辟了一条途径。
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