Wainsztein Néstor, Rodríguez Lucci Federico
Department of Internal Medicine, Neurocritical Care Unit, Institute of Neurological Research, FLENI, Montañeses 2325, Buenos Aires, Argentina.
Department of Internal Medicine, Neurocritical Care Unit, Institute of Neurological Research, FLENI, Montañeses 2325, Buenos Aires, Argentina; Stroke Unit, Comprehensive Stroke Center, Institute of Neurological Research, FLENI, Montañeses 2325, Buenos Aires, Argentina.
Neurol Clin. 2017 Nov;35(4):655-664. doi: 10.1016/j.ncl.2017.06.004.
Spreading depolarization in cerebral cortex is associated with swelling of neurons, distortion of dendritic spines, massive ion translocation with a large change of the slow electrical potential, and silencing of brain electrical activity. The term spreading depression represents a wave of spontaneous activity of the electrocorticogram that propagates through contiguous cerebral gray matter at a characteristic velocity. Spreading depression is a consequence of cortical spreading depolarization. Therefore, spreading depolarization is not always accompanied by spreading depression and the terms are not synonymous.
大脑皮层中的扩散性去极化与神经元肿胀、树突棘扭曲、大量离子转运以及缓慢电位的巨大变化和脑电活动的沉默有关。扩散性抑制这一术语代表了脑电图的自发活动波，它以特征速度在相邻的脑灰质中传播。扩散性抑制是皮层扩散性去极化的结果。因此，扩散性去极化并不总是伴有扩散性抑制，这两个术语不是同义词。
