线粒体与致癌病毒的相互作用。
The interaction between mitochondria and oncoviruses.
机构信息
Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
School of Medicine, Taizhou College, Taizhou, Zhejiang, China.
出版信息
Biochim Biophys Acta Mol Basis Dis. 2018 Feb;1864(2):481-487. doi: 10.1016/j.bbadis.2017.09.023. Epub 2017 Sep 28.
Abstract
Mitochondria play important roles in multiple aspects of viral tumorigenesis. Mitochondrial genomes contribute to the host's genetic background. After viruses enter the cell, they modulate mitochondrial function and thus alter bioenergetics and retrograde signaling pathways. At the same time, mitochondria also regulate and mediate viral oncogenesis. In this context, oncogenesis by oncoviruses like Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human papilloma virus (HPV), Human Immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) will be discussed.
摘要
线粒体在病毒致癌作用的多个方面发挥着重要作用。线粒体基因组有助于宿主的遗传背景。病毒进入细胞后，它们调节线粒体功能，从而改变生物能量和逆行信号通路。与此同时，线粒体也调节和介导病毒致癌作用。在这种情况下，将讨论乙型肝炎病毒 (HBV)、丙型肝炎病毒 (HCV)、人乳头瘤病毒 (HPV)、人类免疫缺陷病毒 (HIV) 和爱泼斯坦-巴尔病毒 (EBV) 等致癌病毒的致癌作用。
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