癌症生物学中的病毒非编码RNA
Viral Noncoding RNAs in Cancer Biology.
作者信息
Li Zhi, Fu Shujun, Sun Lun-Quan
机构信息
Center for Molecular Medicine of Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Central South University, Changsha, Hunan, 410008, China.
Key Laboratory of Molecular Radiation Oncology, Hunan, China.
出版信息
Adv Exp Med Biol. 2016;927:367-89. doi: 10.1007/978-981-10-1498-7_14.
Over 12 % of all human cancers are caused by oncoviruses, primarily including Epstein-Barr virus (EBV), high-risk human papillomaviruses (HPVs), hepatitis B and C viruses (HBV and HCV, respectively), and Kaposi's sarcoma herpesvirus (KSHV). In addition to viral oncoproteins, a variety of noncoding RNAs (ncRNAs) produced by oncoviruses have been recognized as important cofactors that contribute to the oncogenic events. In this chapter, we will focus on the recent understanding of the long and short noncoding RNAs, as well as microRNAs of the viruses, and discuss their roles in the biology of multistep oncogenesis mediated by established human oncoviruses.
超过12%的人类癌症是由致癌病毒引起的，主要包括爱泼斯坦-巴尔病毒（EBV）、高危型人乳头瘤病毒（HPV）、乙型和丙型肝炎病毒（分别为HBV和HCV）以及卡波西肉瘤疱疹病毒（KSHV）。除病毒癌蛋白外，致癌病毒产生的多种非编码RNA（ncRNA）已被认为是促成致癌事件的重要辅助因子。在本章中，我们将重点关注对病毒的长链和短链非编码RNA以及微小RNA的最新认识，并讨论它们在由已确定的人类致癌病毒介导的多步骤肿瘤发生生物学中的作用。
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