Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Mannheim, Germany.
Center for Medical Imaging North-East Netherlands, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
J Thorac Oncol. 2017 Dec;12(12):1755-1765. doi: 10.1016/j.jtho.2017.09.1956. Epub 2017 Sep 27.
Although the effectiveness of screening for lung cancer remains controversial, it is a fact that most lung cancers are diagnosed at an advanced stage outside of lung cancer screening programs. In 2013, the U.S. Preventive Services Task Force revised its lung cancer screening recommendation, now supporting lung cancer screening by low-dose computed tomography in patients at high risk. This is also endorsed by many major medical societies and advocacy group stakeholders, albeit with different eligibility criteria. In Europe, population-based lung cancer screening has so far not been recommended or implemented, as some important issues remain unresolved. Among them is the open question of how enlarging pulmonary nodules detected in lung cancer screening should be managed. This article comprises two parts: a review of the current lung cancer screening approaches and the potential therapeutic options for enlarging pulmonary nodules, followed by a meeting report including consensus statements of an interdisciplinary expert panel that discussed the potential of the different therapeutic options.
虽然肺癌筛查的效果仍存在争议，但大多数肺癌都是在肺癌筛查计划之外的晚期才被诊断出来，这是事实。2013 年，美国预防服务工作组修订了其肺癌筛查建议，现在支持对高危人群进行低剂量计算机断层扫描肺癌筛查。这也得到了许多主要医学协会和倡导团体利益相关者的认可，尽管他们的资格标准不同。在欧洲，迄今为止，基于人群的肺癌筛查尚未被推荐或实施，因为一些重要问题仍未解决。其中包括如何处理肺癌筛查中发现的肺结节增大的问题。本文包括两部分：对当前肺癌筛查方法和增大肺结节的潜在治疗选择的综述，以及包括一个跨学科专家小组共识声明的会议报告，该报告讨论了不同治疗选择的潜力。
