Searle R F, Matthews C J
Department of Anatomy, Medical School, Newcastle upon Tyne, UK.
Placenta. 1988 Jan-Feb;9(1):57-64. doi: 10.1016/0143-4004(88)90073-2.
A differential expression of class II major histocompatibility complex (MHC) and Thy 1.2 antigens was detected on two morphologically distinct cell populations in short-term cultures of murine decidual tissue. Stromal type decidual cells expressed Thy 1.2, albeit transiently, and consistently lacked class II antigens. By contrast decidual macrophages expressed class II antigens and lacked Thy 1.2 antigens. Stromal type decidual cells, after culture in the presence of indomethacin, displayed no evidence of prostaglandin-mediated modulation of class II expression. These findings suggest that class II positive decidual macrophages are responsible for the antigen-presenting capacity of decidua.
在小鼠蜕膜组织短期培养物中的两个形态学上不同的细胞群体上检测到了II类主要组织相容性复合体（MHC）和Thy 1.2抗原的差异表达。基质型蜕膜细胞短暂表达Thy 1.2，并且始终缺乏II类抗原。相比之下，蜕膜巨噬细胞表达II类抗原且缺乏Thy 1.2抗原。在吲哚美辛存在的情况下培养后，基质型蜕膜细胞没有显示出前列腺素介导的II类表达调节的证据。这些发现表明，II类阳性的蜕膜巨噬细胞负责蜕膜的抗原呈递能力。
