Searle R F, Bell S C, Billington W D
Placenta. 1983 Apr-Jun;4(2):139-48. doi: 10.1016/s0143-4004(83)80027-7.
The ontogeny of Ia antigen expression on cells within the decidua basalis of the placenta and on decidual cells differentiating in vitro was investigated in the mouse. The results indicate that Ia antigen expression is temporarily restricted and can be detected in short-term cultures of decidual tissue only during the final third of gestation. The Ia antigen positive cells, which are non-phagocytic, non-specific esterase negative and lack Fc receptors, appear to be true decidual cells on the basis of their fine structural characteristics. In contrast, morphologically identical dendritic decidual cells arising from differentiation in vitro of endometrial cells do not express Ia antigens. A population of small rounded cells was also present in cultures of both decidual tissue and in vitro decidualized endometrial cells. These rounded cells possess the macrophage-like properties of Fc receptors, non-specific esterase and phagocytic activity. The possible function of these cell populations within the decidual tissue is discussed.
在小鼠中研究了胎盘基蜕膜内细胞以及体外分化的蜕膜细胞上Ia抗原表达的个体发生。结果表明，Ia抗原表达受到暂时限制，仅在妊娠最后三分之一期间，在蜕膜组织的短期培养物中才能检测到。Ia抗原阳性细胞为非吞噬性、非特异性酯酶阴性且缺乏Fc受体，根据其精细结构特征，似乎是真正的蜕膜细胞。相比之下，子宫内膜细胞体外分化产生的形态相同的树突状蜕膜细胞不表达Ia抗原。在蜕膜组织培养物和体外蜕膜化的子宫内膜细胞培养物中也都存在一群小圆形细胞。这些圆形细胞具有Fc受体、非特异性酯酶和吞噬活性等巨噬细胞样特性。讨论了这些细胞群在蜕膜组织中的可能功能。
