Scand J Gastroenterol. 1988 Mar;23(2):134-8. doi: 10.3109/00365528809103957.
Trimoprostil is a new synthetic prostaglandin E2 analogue that inhibits acid secretion and has mucosal protective properties. It was compared with cimetidine to assess its effectiveness in the short-term treatment of duodenal ulcer. Seven centres recruited 107 patients, who were randomized to receive either 3 mg trimoprostil daily (n = 54) or 1 g cimetidine daily (n = 53) for 4 weeks, the drugs being taken in four divided doses. Of patients completing treatment, 23 of 40 (58%) healed with trimoprostil, compared with 47 of 53 (89%) with cimetidine (p less than 0.001). Both drugs relieved daytime and nighttime pain, but cimetidine was significantly quicker. Eight patients taking trimoprostil were withdrawn because of pain, nausea, and vomiting, but none taking cimetidine; diarrhoea did not occur with trimoprostil. There were no clinically significant changes in haematology or in biochemistry studies. In conclusion, trimoprostil was not as effective as cimetidine in the treatment of duodenal ulcer.
曲莫前列素是一种新型合成前列腺素E2类似物，具有抑制胃酸分泌和黏膜保护特性。将其与西咪替丁进行比较，以评估其在十二指肠溃疡短期治疗中的有效性。7个中心招募了107名患者，这些患者被随机分为两组，一组每天服用3毫克曲莫前列素（n = 54），另一组每天服用1克西咪替丁（n = 53），为期4周，药物均分4次服用。完成治疗的患者中，40名服用曲莫前列素的患者有23名（58%）愈合，而服用西咪替丁的53名患者中有47名（89%）愈合（p < 0.001）。两种药物均能缓解白天和夜间疼痛，但西咪替丁起效明显更快。8名服用曲莫前列素的患者因疼痛、恶心和呕吐而退出，但服用西咪替丁的患者无人退出；曲莫前列素未导致腹泻。血液学和生物化学研究未出现具有临床意义的变化。总之，曲莫前列素在治疗十二指肠溃疡方面不如西咪替丁有效。
