You Min Ju, Langfield Peter, Campanari Lucas, Dobbs Matt, Shrier Alvin, Glass Leon
Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada.
Department of Physics and McGill Space Institute, McGill University, Montreal, Quebec H3A 2T8, Canada.
Chaos. 2017 Sep;27(9):093938. doi: 10.1063/1.5001459.
Excitable media, such as the heart, display propagating waves with different geometries including target patterns and rotors (spiral waves). Collision of two waves leads to annihilation of both. We present algorithms for data processing and analysis to identify the core of rotors. In this work, we show that as the spatial sampling resolution decreases it becomes increasingly difficult to identify rotors-there are instances of false negatives and false positives. These observations are relevant to current controversies concerning the role of rotors in the initiation, maintenance, and treatment of cardiac arrhythmias, especially atrial fibrillation. Currently some practitioners target the core of rotors for ablation, but the effectiveness of this procedure has been questioned. In view of the difficulties inherent in the identification of rotors, we conclude that methods to identify rotors need to first be validated prior to assessing the efficacy of ablation.
可兴奋介质，如心脏，会呈现出具有不同几何形状的传播波，包括靶形图案和转子（螺旋波）。两列波碰撞会导致两者都湮灭。我们提出了用于数据处理和分析的算法，以识别转子的核心。在这项工作中，我们表明，随着空间采样分辨率的降低，识别转子变得越来越困难——存在假阴性和假阳性的情况。这些观察结果与当前关于转子在心律失常（尤其是心房颤动）的发生、维持和治疗中的作用的争议相关。目前，一些从业者将转子核心作为消融靶点，但该手术的有效性受到了质疑。鉴于识别转子存在固有的困难，我们得出结论，在评估消融疗效之前，识别转子的方法需要首先得到验证。
