Spampinato Maria Vittoria, Abid Ahad, Matheus Maria Gisele
Department of Radiology and Radiological Science, Medical University of South Carolina, 96 Jonathan Lucas Street MSC 323, Charleston, SC 29425, USA.
School of Medicine, University of South Carolina, 6311 Garners Ferry Road, Columbia, SC 29209, USA.
Magn Reson Imaging Clin N Am. 2017 Nov;25(4):697-704. doi: 10.1016/j.mric.2017.06.003. Epub 2017 Aug 23.
Millions of radiologic examinations requiring the use of iodinated contrast are performed yearly in North America. Triiodobenzoic acid, the contrast agent molecule currently in use, is a benzene ring covalently bonded to the 3 iodine atoms. Iodinated contrast media can be divided in 4 categories: ionic monomers, ionic dimers, nonionic monomer, and nonionic dimers. Currently, second- and third-generation nonionic low-osmolar and iso-osmolar contrast media are used in clinical practice. The search for a safer and more effective iodinated contrast agents remains an ongoing challenge and important research topic.
在北美，每年都要进行数百万次需要使用碘化造影剂的放射学检查。目前使用的造影剂分子三碘苯甲酸是一个与3个碘原子共价键合的苯环。碘化造影剂可分为4类：离子单体、离子二聚体、非离子单体和非离子二聚体。目前，第二代和第三代非离子低渗和等渗造影剂在临床实践中使用。寻找更安全、更有效的碘化造影剂仍然是一个持续的挑战和重要的研究课题。
