School of Biological Sciences, Monash University, Clayton, Victoria 3800, Australia.
Max Planck Institute for Biology of Ageing, Köln 50931, Germany; Institute of Healthy Ageing, Department GEE, UCL, Darwin Building, Gower Street, London, WC1E 6BT, UK.
Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2707-2717. doi: 10.1016/j.bbadis.2017.09.016. Epub 2017 Sep 28.
Drosophila melanogaster has been a key model in developing our current understanding of the molecular mechanisms of ageing. Of particular note is its role in establishing the evolutionary conservation of reduced insulin and IGF-1-like signaling in promoting healthy ageing. Capitalizing on its many advantages for experimentation, more recent work has revealed how precise nutritional and genetic interventions can improve fly lifespan without obvious detrimental side effects. We give a brief summary of these recent findings as well as examples of how they may modify ageing via actions in the gut and muscle. These discoveries highlight how expanding our understanding of metabolic and signaling interconnections will provide even greater insight into how these benefits may be harnessed for anti-ageing interventions.
果蝇一直是我们当前理解衰老分子机制的关键模型。特别值得注意的是，它在建立胰岛素和 IGF-1 样信号降低的进化保守性以促进健康衰老方面发挥了作用。利用其在实验方面的诸多优势，最近的研究揭示了精确的营养和遗传干预如何在没有明显不利副作用的情况下提高苍蝇的寿命。我们简要总结了这些最新发现，并举例说明了它们如何通过在肠道和肌肉中的作用来改变衰老。这些发现强调了如何扩展我们对代谢和信号相互联系的理解，将为我们如何利用这些益处进行抗衰老干预提供更深入的认识。
