Ascott Anna, Yu Ashley M, Schmidt Morten, Abuabara Katrina, Smeeth Liam, Langan Sinéad M
Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
BMJ Open. 2017 Sep 29;7(9):e017979. doi: 10.1136/bmjopen-2017-017979.
Chronic inflammatory diseases such as eczema (also known as atopic dermatitis) have been inconsistently linked to cardiovascular disease and stroke in both mechanistic and epidemiological studies. There is a need to review the existing epidemiological data examining the association between eczema and major cardiovascular outcomes, including angina, myocardial infarction, coronary revascularisation, heart failure, cardiac arrhythmias, stroke and cardiovascular death, in order to improve our understanding of the comorbidities of eczema.
We will systematically review population-based studies, including cohort, case-control and cross-sectional studies, reporting on the association between eczema and cardiovascular outcomes. We will search Medline, Embase and Global Health, from their date of inception to April 2017, using a comprehensive search strategy formulated with the help of a librarian. Two reviewers will independently screen titles and abstracts in duplicate, followed by independent data extraction and quality assessment. We will group studies by the cardiovascular outcome under study and synthesise them narratively. If sufficient numbers of homogeneous studies are returned, we will perform meta-analyses to obtain pooled effect estimates. Preferred Reporting Items for Systematic Review and Meta-Analysis will be used to inform the reporting of this study.
CRD42017060359.
在机制研究和流行病学研究中，湿疹（也称为特应性皮炎）等慢性炎症性疾病与心血管疾病和中风之间的联系并不一致。有必要回顾现有的流行病学数据，以研究湿疹与主要心血管结局之间的关联，这些结局包括心绞痛、心肌梗死、冠状动脉血运重建、心力衰竭、心律失常、中风和心血管死亡，从而增进我们对湿疹合并症的理解。
我们将系统回顾基于人群的研究，包括队列研究、病例对照研究和横断面研究，这些研究报告了湿疹与心血管结局之间的关联。我们将检索Medline、Embase和Global Health数据库，检索时间从各数据库创建之日至2017年4月，使用在一名图书馆员帮助下制定的全面检索策略。两名评价员将独立对标题和摘要进行重复筛选，随后进行独立的数据提取和质量评估。我们将根据所研究的心血管结局对研究进行分组，并进行叙述性综合分析。如果返回足够数量的同类研究，我们将进行荟萃分析以获得合并效应估计值。本研究的报告将采用系统评价和荟萃分析的首选报告项目。
CRD42017060359。
