Nutrition-Minerals Laboratory, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580-Bloco 14, Butantã, 05508900, SP, Brazil.
Department of Nutrition, Federal University of Sergipe, Avenida Marechal Rondon, S/n - Jardim Rosa Elze, 49100000, São Cristovão, Sergipe, Brazil.
J Trace Elem Med Biol. 2017 Dec;44:132-136. doi: 10.1016/j.jtemb.2017.07.004. Epub 2017 Jul 12.
This study evaluated the relationship between the zinc-related nutritional status and glycemic and insulinemic markers in individuals with type 2 diabetes mellitus (T2DM). A total of 82 individuals with T2DM aged between 29 and 59 years were evaluated. The concentration of zinc in the plasma, erythrocytes, and urine was determined by the flame atomic absorption spectrometry method. Dietary intake was assessed using a 3-day 24-h recall. In addition, concentrations of serum glucose, glycated hemoglobin percentage, total cholesterol and fractions, triglycerides, and serum insulin were determined. The insulin resistance index (HOMA-IR) and β-cell function (HOMA- β) were calculated. The markers of zinc status (plasma: 83.3±11.9μg/dL, erythrocytes: 30.1±4.6μg/g Hb, urine: 899.1±622.4μg Zn/24h, and dietary: 9.9±0.8mg/day) were classified in tertiles and compared to insulinemic and glycemic markers. The results showed that lower zinc concentrations in plasma and erythrocytes, as well as its high urinary excretion, were associated with higher percentages of glycated hemoglobin, reflecting a worse glycemic control in individuals with T2DM (p<0.05). Furthermore, there was a significant inverse correlation between plasma zinc levels and glycated hemoglobin percentage (r=-0.325, p=0.003), and a positive correlation between urinary zinc excretion and glycemia (r=0.269, p=0.016), glycated hemoglobin percentage (r=0.318, p=0.004) and HOMA-IR (r=0.289, p=0.009). According to our study results, conclude that T2DM individuals with reduced zinc status exhibited poor glycemic control.
本研究评估了 2 型糖尿病（T2DM）个体中锌相关营养状况与血糖和胰岛素指标之间的关系。共评估了 82 名年龄在 29 至 59 岁之间的 T2DM 个体。通过火焰原子吸收光谱法测定血浆、红细胞和尿液中的锌浓度。使用 3 天 24 小时回顾法评估膳食摄入量。此外，还测定了血清葡萄糖、糖化血红蛋白百分比、总胆固醇及其各部分、甘油三酯和血清胰岛素的浓度。计算胰岛素抵抗指数（HOMA-IR）和β细胞功能（HOMA- β）。将锌状态标志物（血浆：83.3±11.9μg/dL，红细胞：30.1±4.6μg/gHb，尿液：899.1±622.4μg Zn/24h，膳食：9.9±0.8mg/天）分为三分位，并与胰岛素和血糖标志物进行比较。结果表明，血浆和红细胞中锌浓度较低，以及其高尿排泄，与糖化血红蛋白百分比升高相关，提示 T2DM 个体血糖控制较差（p<0.05）。此外，血浆锌水平与糖化血红蛋白百分比呈显著负相关（r=-0.325，p=0.003），尿锌排泄与血糖（r=0.269，p=0.016）、糖化血红蛋白百分比（r=0.318，p=0.004）和 HOMA-IR（r=0.289，p=0.009）呈正相关。根据我们的研究结果，得出结论，锌状态降低的 T2DM 个体表现出较差的血糖控制。
