Department of Radiology and Radiological Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Department of Radiology and Radiological Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA; Department of Oncology, Johns Hopkins University, School of Medicine, MD, USA.
Biochim Biophys Acta Rev Cancer. 2017 Dec;1868(2):510-520. doi: 10.1016/j.bbcan.2017.09.006. Epub 2017 Sep 28.
Cancer cells are reliant on the cellular translational machinery for both global elevation of protein synthesis and the translation of specific mRNAs that promote tumor cell survival. Targeting translational control in cancer is therefore increasingly recognized as a promising therapeutic strategy. In this regard, DEAD/H box RNA helicases are a very interesting group of proteins, with several family members regulating mRNA translation in cancer cells. In this review, we delineate the mechanisms by which DEAD/H box proteins modulate oncogenic translation and how inhibition of these RNA helicases can be exploited for anti-cancer therapeutics.
癌细胞依赖细胞翻译机制来提高蛋白质合成的整体水平，并翻译特定的促进肿瘤细胞存活的 mRNA。因此，靶向癌症中的翻译控制被认为是一种很有前途的治疗策略。在这方面，DEAD/H 盒 RNA 解旋酶是一组非常有趣的蛋白质，有几个家族成员调节癌细胞中的 mRNA 翻译。在这篇综述中，我们阐述了 DEAD/H 盒蛋白调节致癌翻译的机制，以及如何利用这些 RNA 解旋酶的抑制作用来进行抗癌治疗。
