Mowla Alireza, Du Benjamin Wensheng, Taimre Thomas, Bertling Karl, Wilson Stephen, Soyer H Peter, Rakić Aleksandar D
The University of Queensland, School of Information Technology and Electrical Engineering, St. Lucia, Brisbane, 4072, Australia.
The University of Queensland, School of Mathematics and Physics, St. Lucia, Brisbane, 4072, Australia.
Biomed Opt Express. 2017 Aug 10;8(9):4037-4048. doi: 10.1364/BOE.8.004037. eCollection 2017 Sep 1.
Tomographic imaging of soft tissue such as skin has a potential role in cancer detection. The penetration of infrared wavelengths makes a confocal approach based on laser feedback interferometry feasible. We present a compact system using a semiconductor laser as both transmitter and receiver. Numerical and physical models based on the known optical properties of keratinocyte cancers were developed. We validated the technique on three phantoms containing macro-structural changes in optical properties. Experimental results were in agreement with numerical simulations and structural changes were evident which would permit discrimination of healthy tissue and tumour. Furthermore, cancer type discrimination was also able to be visualized using this imaging technique.
对皮肤等软组织进行断层成像在癌症检测中具有潜在作用。红外波长的穿透性使基于激光反馈干涉测量法的共聚焦方法成为可能。我们展示了一种使用半导体激光器作为发射器和接收器的紧凑型系统。基于角质形成细胞癌已知光学特性建立了数值模型和物理模型。我们在三个光学特性存在宏观结构变化的模型上验证了该技术。实验结果与数值模拟一致，结构变化明显，这将有助于区分健康组织和肿瘤。此外，使用这种成像技术还能够实现癌症类型的鉴别可视化。
