O'Brien Melissa, Philpott Holly T, McDougall Jason J
Departments of Pharmacology and Anaesthesia, Pain Management & Perioperative Medicine, Dalhousie University, Halifax, Canada.
Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):47-52. Epub 2017 Sep 28.
Osteoarthritis (OA) is the most prevalent musculoskeletal disease worldwide. Chronic pain remains the foremost concern of OA patients and is poorly controlled by available pharmacotherapies. Current preclinical research, which aims to develop analgesics better suited for OA, is largely dependent on animal models and laboratory pain testing. This review summarises commonly used small animal models for studying experimental OA, including their benefits and limitations. Also discussed are a variety of validated methods for studying pain within these models.
骨关节炎（OA）是全球最普遍的肌肉骨骼疾病。慢性疼痛仍然是OA患者最主要的担忧，并且现有的药物治疗对其控制效果不佳。目前旨在开发更适合OA的镇痛药的临床前研究在很大程度上依赖于动物模型和实验室疼痛测试。这篇综述总结了用于研究实验性OA的常用小动物模型，包括它们的优点和局限性。还讨论了在这些模型中研究疼痛的各种经过验证的方法。
