小动物骨关节炎疼痛模型的述评。
A commentary on modelling osteoarthritis pain in small animals.
机构信息
Department of Medicine, Section of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
出版信息
Osteoarthritis Cartilage. 2013 Sep;21(9):1316-26. doi: 10.1016/j.joca.2013.06.003.
Abstract
OBJECTIVE
To describe the currently used animal models for the study of osteoarthritis (OA) pain, with an emphasis on small animals (predominantly mice and rats).
OUTLINE
Narrative review summarizing the opportunities and limitations of the most commonly used small animal models for the study of pain and pain pathways associated with OA, and discussing currently used methods for pain assessment. Involvement of neural degeneration in OA is briefly discussed. A list of considerations when studying pain-related behaviours and pathways in animal models of OA is proposed.
CONCLUSIONS
Animal models offer great potential to unravel the complex pathophysiology of OA pain, its molecular and temporal regulation. They constitute a critical pathway for developing and testing disease-specific symptom-modifying therapeutic interventions. However, a number of issues remain to be resolved in order to standardize pre-clinical OA pain research and to optimize translation to clinical trials and patient therapies.
摘要
目的
描述目前用于骨关节炎（OA）疼痛研究的动物模型，重点是小动物（主要是小鼠和大鼠）。
概述
本文是一篇综述，总结了最常用于研究与 OA 相关的疼痛和疼痛通路的小动物模型的优缺点，并讨论了目前用于疼痛评估的方法。简要讨论了神经退行性变在 OA 中的作用。提出了在 OA 动物模型中研究与疼痛相关的行为和途径时需要考虑的因素列表。
结论
动物模型为揭示 OA 疼痛的复杂病理生理学及其分子和时间调节提供了巨大的潜力。它们是开发和测试针对疾病的症状改善治疗干预的关键途径。然而，为了使 OA 疼痛的临床前研究标准化，并优化向临床试验和患者治疗的转化，仍有一些问题需要解决。
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