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骨关节炎动物模型中的疼痛评估。

Pain assessment in animal models of osteoarthritis.

机构信息

Comparative Medicine Consultants, Chicago, IL 60631, USA.

Department of Anesthesiology, Rush University Medical Center, Chicago, IL 60612, USA.

出版信息

Gene. 2014 Mar 10;537(2):184-8. doi: 10.1016/j.gene.2013.11.091. Epub 2013 Dec 10.

DOI:10.1016/j.gene.2013.11.091
PMID:24333346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3950312/
Abstract

Assessment of pain in animal models of osteoarthritis is integral to interpretation of a model's utility in representing the clinical condition, and enabling accurate translational medicine. Here we describe behavioral pain assessments available for small and large experimental osteoarthritic pain animal models.

摘要

评估骨关节炎动物模型的疼痛对于解释模型在代表临床状况方面的效用以及实现准确的转化医学至关重要。本文介绍了小型和大型实验性骨关节炎疼痛动物模型中可用的行为疼痛评估方法。

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本文引用的文献

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Arthritis. 2012;2012:764621. doi: 10.1155/2012/764621. Epub 2012 Dec 27.
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Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20602-7. doi: 10.1073/pnas.1209294110. Epub 2012 Nov 26.
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Clinical validity of outcome pain measures in naturally occurring canine osteoarthritis.自然发生的犬骨关节炎结局疼痛测量的临床有效性。
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Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis.犬类简短疼痛量表检测骨关节炎犬对治疗反应的能力。
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Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain.在神经性疼痛小鼠模型中，谷氨酸受体配体可减轻异常性疼痛和痛觉过敏，并增强吗啡的作用。
Pain. 2008 Sep 30;139(1):117-126. doi: 10.1016/j.pain.2008.03.017. Epub 2008 Apr 28.
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