负调控因子CXXC5：让WNT看起来没那么紊乱
The Negative Regulator CXXC5: Making WNT Look a Little Less Dishevelled.
作者信息
Kim Dongwon, Garza Luis A
机构信息
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
J Invest Dermatol. 2017 Nov;137(11):2248-2250. doi: 10.1016/j.jid.2017.07.826. Epub 2017 Sep 27.
Abstract
Wingless-related integration site (WNT)/β-catenin signaling regulates diverse physiological functions including tissue regeneration. Activation of WNT signaling can be inhibited by various agents. Lee et al. investigate the interaction of CXXC-type zinc finger protein 5 (CXXC5) with Dishevelled as one such negative regulator of WNT in hair follicle regeneration.
摘要
无翅相关整合位点（WNT）/β-连环蛋白信号传导调节多种生理功能，包括组织再生。WNT信号传导的激活可被多种试剂抑制。李等人研究了CXXC型锌指蛋白5（CXXC5）与蓬乱蛋白的相互作用，CXXC5是毛囊再生中WNT的一种负调节因子。
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本文引用的文献
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Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis.一种竞争性肽靶向CXXC5可刺激毛发生长和伤口诱导的毛发新生。
J Invest Dermatol. 2017 Nov;137(11):2260-2269. doi: 10.1016/j.jid.2017.04.038. Epub 2017 Jun 6.
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ThPOK represses CXXC5, which induces methylation of histone H3 lysine 9 in Cd40lg promoter by association with SUV39H1: implications in repression of CD40L expression in CD8+ cytotoxic T cells.ThPOK抑制CXXC5，CXXC5通过与SUV39H1结合诱导Cd40lg启动子中组蛋白H3赖氨酸9的甲基化：对CD8 + 细胞毒性T细胞中CD40L表达抑制的影响
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The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing.与蓬乱蛋白结合的CXXC5蛋白对皮肤伤口愈合起负向调节作用。
J Exp Med. 2015 Jun 29;212(7):1061-80. doi: 10.1084/jem.20141601. Epub 2015 Jun 8.
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Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.CXXC 结构域蛋白 IDAX 对 TET2 表达和 5-甲基胞嘧啶氧化的调节。
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