Cognitive Neuropsychiatry Team / Voices Clinic, Monash Alfred Psychiatry Research Centre, Alfred Hospital and Monash University Central Clinical School, Melbourne, Australia.
Cognitive Neuropsychiatry Team / Voices Clinic, Monash Alfred Psychiatry Research Centre, Alfred Hospital and Monash University Central Clinical School, Melbourne, Australia; Department of Psychiatry, St. Vincent's Hospital, Melbourne, Australia; Brain and Psychological Sciences Research Centre, Swinburne University of Technology, Melbourne, Australia.
Psychiatry Res. 2018 Apr;262:494-499. doi: 10.1016/j.psychres.2017.09.031. Epub 2017 Sep 14.
Approaches to cognitive remediation (CR) that address sensory perceptual skills before higher cognitive skills, have been found to be effective in enhancing cognitive performance in schizophrenia. To date, however, most of the conducted trials have concentrated on auditory processing. The aim of this study was to explore whether the addition of visual processing training could enhance standard cognitive remediation outcomes in a schizophrenia population. Twenty participants were randomised to either receive 20h of computer-assisted cognitive remediation alone or 20h of visual processing training modules and cognitive remediation training. All participants were assessed at baseline and at the end of cognitive remediation training on cognitive and psychosocial (i.e. self-esteem, quality of life) measures. At the end of the study participants across both groups improved significantly in overall cognition and psychosocial functioning. No significant differences were observed between groups on any of the measures. Of potential interest, however, was that the Cohen's d assessing the between group difference in the rates of change were moderate/large for a greater improvement in Visual Learning, Working Memory and Social Cognition for the visual training plus cognitive remediation group. On the basis of our effect sizes on three domains of cognition, we recommend replicating this intervention with a larger sample.
在治疗精神分裂症患者的认知障碍时，先处理感觉知觉技能，再处理更高阶认知技能的方法，已被证实能有效提升认知表现。然而，迄今为止，大多数已进行的试验都集中在听觉处理上。本研究旨在探讨在精神分裂症患者中，加入视觉处理训练是否能增强标准认知矫正的效果。二十名参与者被随机分配至接受 20 小时的计算机辅助认知矫正，或接受 20 小时的视觉处理训练模块和认知矫正训练。所有参与者在认知矫正训练前和结束时，均接受认知和心理社会（如自尊、生活质量）测量。在研究结束时，两组参与者在整体认知和心理社会功能方面均有显著改善。两组在任何测量指标上均未观察到显著差异。然而，有趣的是，评估视觉训练加认知矫正组在视觉学习、工作记忆和社会认知方面的变化率的 Cohen's d 值为中到大，表明该组有更大的改善。基于我们在三个认知领域的效应大小，我们建议用更大的样本重复进行这项干预。
