Isaksson R, Sandström J, Eliaz M, Israely Z, Agranat I
Division of Organic Chemistry, University of Lund, Sweden.
J Pharm Pharmacol. 1988 Jan;40(1):48-50. doi: 10.1111/j.2042-7158.1988.tb05148.x.
Nefopam, a potent analgesic, has been completely resolved into enantiomers on a preparative scale by low-pressure liquid chromatography on swollen, microcrystalline triacetylcellulose. The enantiomerically pure hydrochlorides were prepared from the base, and the circular dichroism spectra of the free base and the hydrochloride are reported.
