Enantiomer resolution of nefopam hydrochloride, a novel analgesic: a study by liquid chromatography and circular dichroism spectroscopy.
作者信息
Isaksson R, Sandström J, Eliaz M, Israely Z, Agranat I
机构信息
Division of Organic Chemistry, University of Lund, Sweden.
出版信息
J Pharm Pharmacol. 1988 Jan;40(1):48-50. doi: 10.1111/j.2042-7158.1988.tb05148.x.
Abstract
Nefopam, a potent analgesic, has been completely resolved into enantiomers on a preparative scale by low-pressure liquid chromatography on swollen, microcrystalline triacetylcellulose. The enantiomerically pure hydrochlorides were prepared from the base, and the circular dichroism spectra of the free base and the hydrochloride are reported.
摘要
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