奈福泮对家兔血液酸碱状态的影响：与吗啡在家鼠和家兔体内的相互作用。

The effects of nefopam on blood acid-base status in the rabbit: interactions with morphine in the mouse and rabbit.

作者信息

Stainthorp S F, Morton A K, Pleuvry B J

出版信息

J Pharm Pharmacol. 1980 Oct;32(10):689-92. doi: 10.1111/j.2042-7158.1980.tb13039.x.

DOI:10.1111/j.2042-7158.1980.tb13039.x

Abstract

Nefopam, a non-narcotic analgesic, had only minor effects upon the blood pH, PCO2 and standard bicarbonate of the conscious rabbit. In contrast morphine caused a dose-dependent increase in PCO2 and standard bicarbonate. When nefopam was administered in conjunction with morphine (2.5 mg kg-1 and 1 mg kg-1 i.v. respectively) the increase in PCO2 was greater than with morphine alone. Nefopam also increased the antinociceptive and respiratory frequency depressant effects of morphine in the mouse.

摘要

奈福泮是一种非麻醉性镇痛药，对清醒家兔的血液pH值、二氧化碳分压和标准碳酸氢盐仅有轻微影响。相比之下，吗啡会导致二氧化碳分压和标准碳酸氢盐呈剂量依赖性增加。当奈福泮与吗啡联合给药时（分别静脉注射2.5毫克/千克和1毫克/千克），二氧化碳分压的升高幅度大于单独使用吗啡时。奈福泮还增强了吗啡对小鼠的镇痛作用和呼吸频率抑制作用。