Conway A C, Mitchell C L
Arch Int Pharmacodyn Ther. 1977 Mar;226(1):156-71.
Nefopam hydrochloride[3] is a novel analgesic agent possessing an activity profile distinct from that of narcotic, narcotic agonist-antagonist and analgesic antiinflammatory agents. Analgesic activity is demonstrated in a variety of laboratory procedures with rodents, cats and monkeys. The analgesic potency of nefopam hydrochloride is generally similar to that of codeine phosphate. The compound lacks potential for tolerance development and does not exhibit cross-tolerance with morphine sulfate.
盐酸奈福泮[3]是一种新型镇痛药，其活性特征与麻醉性镇痛药、麻醉性激动 - 拮抗剂及镇痛抗炎药不同。在多种针对啮齿动物、猫和猴的实验室实验中均证实了其镇痛活性。盐酸奈福泮的镇痛效力通常与磷酸可待因相似。该化合物不存在产生耐受性的可能性，且与硫酸吗啡不存在交叉耐受性。
