a Laboratory of Molecular Pharmacology, Department of Pharmaceutical Sciences , School of Health Sciences, University of Brasilia , Brazil.
b Laboratory of Biochemical Nutrition, Department of Nutrition , School of Health Sciences, University of Brasilia , Brazil.
Crit Rev Food Sci Nutr. 2019;59(4):652-663. doi: 10.1080/10408398.2017.1386159. Epub 2017 Nov 3.
Coffee consumption is associated with reduced risk of conditions that share low-grade inflammation as their physiopathological basis. We therefore summarized the effects of coffee or coffee components on serum levels of inflammatory markers. Clinical trials assessing the effect of coffee, caffeine or other coffee components on inflammatory markers were searched without restriction to publication date. Fifteen studies (8 involving coffee and 7 caffeine) were included. Increased adiponectin levels were found in four of seven trials comparing filtered coffee/caffeinated coffee with placebo or comparing its levels at baseline and after consumption of medium or dark roasted coffee, but no change was seen in caffeine trials. None of the five studies assessing the effects of coffee found changes in C-reactive protein (CPR), but one out of three trials found decreased CPR levels in response to caffeine. Interleukin (IL)-6 was increased by caffeinated coffee compared with placebo in one of four coffee trials, and by caffeine in three out of five studies. Caffeine increased IL-10 levels in two of three trials. These data suggest a predominant anti-inflammatory action of coffee but not of caffeine consumption. Moreover, the proinflammatory and anti-inflammatory responses to caffeine point to its complex effects on the inflammatory response.
咖啡的摄入与某些疾病的风险降低有关，这些疾病的病理生理基础是低度炎症。因此，我们总结了咖啡或咖啡成分对血清炎症标志物水平的影响。检索了评估咖啡、咖啡因或其他咖啡成分对炎症标志物影响的临床试验，未对发表日期进行限制。共纳入 15 项研究（8 项涉及咖啡，7 项咖啡因）。与安慰剂或比较中、深度烘焙咖啡饮用前后自身水平相比，有 4 项比较过滤咖啡/含咖啡因咖啡的试验发现，咖啡饮用可使脂联素水平升高，但咖啡因试验未见变化。评估咖啡影响的 5 项研究均未发现 C 反应蛋白（CPR）变化，但 3 项试验中的 1 项发现咖啡因可降低 CPR 水平。与安慰剂相比，含咖啡因咖啡可使其中 4 项咖啡试验中的白细胞介素（IL）-6 水平升高，5 项咖啡因试验中的 3 项升高。有 2 项试验发现咖啡因可升高 IL-10 水平。这些数据表明咖啡具有主要的抗炎作用，但咖啡因的摄入没有这种作用。此外，咖啡因对炎症反应的促炎和抗炎作用表明其对炎症反应的作用复杂。
