Feng Ji-Feng, Wang Liang, Jiang You-Hua, Yang Xun
Department of Thoracic Oncological Surgery, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, No.38 Guangji Road, Hangzhou 310022, China.
Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, No. 38 Guangji Road, Zhejiang Province, Hangzhou 310022, China.
J Oncol. 2019 Jul 14;2019:4359103. doi: 10.1155/2019/4359103. eCollection 2019.
The inflammation and nutrition play an important role in prognosis. A novel index combined with inflammatory and nutritional biomarkers, named C-reactive protein (CRP) to prealbumin (PALB) ratio (CPR), was initially reported to predict the prognosis in resectable esophageal squamous cell carcinoma (ESCC).
A retrospective study was conducted including 346 resectable ESCC patients. The X-tile program was used to confirm the optimal cut-off value. The Kaplan-Meier methods and Cox regression analyses were performed to analyze the cancer-specific survival (CSS) and overall survival (OS).
The optimum cut-off point was 0.03 for CPR. Patients with a high level of CPR (> 0.03) were associated with poor CSS (12.0% vs. 43.0%, <0.001) and OS (11.2% vs. 40.7%, <0.001). Multivariate analyses revealed that CPR was an independent predictor in resectable ESCC patients (CSS, =0.008; OS, =0.007).
This study, to the best of our knowledge, is the first to investigate prognostic role of CPR in patients with ESCC. Our retrospective observations indicate that CPR, with the optimal cut-off value of 0.03, is a useful potential predictor in resectable ESCC patients.
炎症和营养在预后中起重要作用。一种结合炎症和营养生物标志物的新型指标，即C反应蛋白（CRP）与前白蛋白（PALB）的比值（CPR），最初被报道可预测可切除食管鳞状细胞癌（ESCC）的预后。
进行了一项回顾性研究，纳入346例可切除的ESCC患者。使用X-tile程序确定最佳临界值。采用Kaplan-Meier方法和Cox回归分析来分析癌症特异性生存（CSS）和总生存（OS）。
CPR的最佳临界值为0.03。CPR水平高（>0.03）的患者CSS较差（12.0%对43.0%，<0.001），OS也较差（11.2%对40.7%，<0.001）。多变量分析显示，CPR是可切除ESCC患者的独立预测指标（CSS，=0.008；OS，=0.007）。
据我们所知，本研究是首次调查CPR在ESCC患者中的预后作用。我们的回顾性观察表明，CPR的最佳临界值为0.03，是可切除ESCC患者有用的潜在预测指标。
