血清 C-反应蛋白在食管癌中的预后作用：系统评价和荟萃分析。
Prognostic role of serum C-reactive protein in esophageal cancer: a systematic review and meta-analysis.
机构信息
Department of Operating Theatre, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
出版信息
Ther Clin Risk Manag. 2015 Jan 21;11:89-94. doi: 10.2147/TCRM.S70954. eCollection 2015.
BACKGROUND
Recent studies have shown that C-reactive protein (CRP) is a useful predictive factor in several cancers; however, its role in esophageal cancer (EC) is controversial.
METHODS
A systematic literature search was performed using Medline, PubMed, and Web of Science to analyze the prognostic value of serum CRP in patients with EC. A meta-analysis was performed to assess the association between serum CRP and overall survival (OS) in patients with EC.
RESULTS
A total of eight studies involving 1,471 patients were included in our study. Our pooled results demonstrated that a high level of serum CRP was associated with poor OS (hazard ratio [HR]: 1.40, 95% confidence interval [CI]: 1.25-1.57, I (2)=81.3%, P<0.0001). Subgroup analyses were performed in further investigations. When the patients were segregated according to treatment, pathological type, and cut-off level, high levels of serum CRP were found to be significantly correlated with OS.
CONCLUSION
Our meta-analysis revealed that high levels of serum CRP were significantly associated with poor OS in patients with EC.
背景
最近的研究表明 C 反应蛋白（CRP）在多种癌症中是一个有用的预测因素；然而，其在食管癌（EC）中的作用仍存在争议。
方法
我们通过 Medline、PubMed 和 Web of Science 进行了系统的文献检索，以分析血清 CRP 对 EC 患者预后的预测价值。进行荟萃分析以评估血清 CRP 与 EC 患者总生存期（OS）之间的相关性。
结果
我们的研究共纳入了 8 项涉及 1471 名患者的研究。我们的汇总结果表明，高水平的血清 CRP 与较差的 OS 相关（风险比 [HR]：1.40，95%置信区间 [CI]：1.25-1.57，I²=81.3%，P<0.0001）。进一步的亚组分析表明，当根据治疗、病理类型和截断值对患者进行分组时，高水平的血清 CRP 与 OS 显著相关。
结论
我们的荟萃分析表明，高水平的血清 CRP 与 EC 患者的 OS 不良显著相关。
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