Zhu Yunyun, Qiu Yiguo, Yu Hongsong, Yi Shenglan, Su Wencheng, Kijlstra Aize, Yang Peizeng
The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China.
University Eye Clinic Maastricht, Maastricht, The Netherlands.
Oncotarget. 2017 Jul 22;8(38):64263-64272. doi: 10.18632/oncotarget.19500. eCollection 2017 Sep 8.
The pathogenesis of Behcet's disease (BD) remains poorly understood. The purpose of this study was to investigate whether an aberrant DNA methylation of transcriptional and inflammatory factors, including and , in CD4T confers risk to BD. We found that the promoter methylation level of and was significantly up-regulated in active BD patients and negatively correlated with the corresponding mRNA expression. The mRNA expression of and was markedly down-regulated in active BD patients compared to healthy individuals. Treatment with corticosteroids and cyclosporine (CsA) resulted in a decrease of the methylation level of and in inactive BD patients. Our results suggest that an aberrant DNA methylation of and is associated with their mRNA expression and participates in the pathogenesis of BD.
白塞病（BD）的发病机制仍未完全明确。本研究旨在探讨CD4T细胞中转录因子和炎症因子（包括[具体因子1]和[具体因子2]）的异常DNA甲基化是否会增加患BD的风险。我们发现，在活动期BD患者中，[具体因子1]和[具体因子2]的启动子甲基化水平显著上调，且与相应的mRNA表达呈负相关。与健康个体相比，活动期BD患者中[具体因子1]和[具体因子2]的mRNA表达明显下调。使用皮质类固醇和环孢素（CsA）治疗可使非活动期BD患者中[具体因子1]和[具体因子2]的甲基化水平降低。我们的结果表明，[具体因子1]和[具体因子2]的异常DNA甲基化与其mRNA表达相关，并参与了BD的发病机制。
