Chen Eric, Bohm Kelley, Rosenblatt Mark, Kang Kai
Illinois Eye and Ear Infirmary, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, United States.
Illinois Eye and Ear Infirmary, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, United States.
Ocul Surf. 2020 Jul;18(3):383-395. doi: 10.1016/j.jtos.2020.04.001. Epub 2020 Apr 25.
In recent years, technological advances in sequencing have accelerated our understanding of epigenetics in ocular development and ophthalmic diseases. We now know that epigenetic modifications are necessary for normal ocular development and biological processes such as corneal wound healing and ocular surface repair, while aberrant epigenetic regulation underlies the pathogenesis of a wide range of ocular diseases, including cataracts and various diseases of the ocular surface. As the epigenetics of the eye is a constantly changing field of medicine, this comprehensive review focuses on innovations and scientific discoveries related to epigenetic control of anterior segment diseases that were published in the English literature in the past five years. These recent studies attempt to elucidate therapeutic targets for the anterior segment pathological processes. Already, recent studies have shown therapeutic potential in targeting epigenetic mechanisms of ocular diseases, and new epigenetic therapies are on the verge of being introduced to clinical practice. New drug targets can potentially emerge as we make further discoveries within this field.
近年来，测序技术的进步加速了我们对眼部发育和眼科疾病中表观遗传学的理解。我们现在知道，表观遗传修饰对于正常的眼部发育以及诸如角膜伤口愈合和眼表修复等生物学过程是必需的，而异常的表观遗传调控是包括白内障和各种眼表疾病在内的多种眼部疾病发病机制的基础。由于眼部表观遗传学是一个不断变化的医学领域，本综述聚焦于过去五年发表在英文文献中与眼前节疾病表观遗传控制相关的创新和科学发现。这些最新研究试图阐明眼前节病理过程的治疗靶点。近期研究已经显示出针对眼部疾病表观遗传机制的治疗潜力，新的表观遗传疗法即将引入临床实践。随着我们在该领域取得进一步发现，新的药物靶点可能会出现。
