鉴定人疱疹病毒6型为幼儿急疹的病原体。

Identification of human herpesvirus-6 as a causal agent for exanthem subitum.

作者信息

Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo T, Asano Y, Kurata T

机构信息

Department of Virology, Osaka University, Japan.

出版信息

Lancet. 1988 May 14;1(8594):1065-7. doi: 10.1016/s0140-6736(88)91893-4.

DOI:10.1016/s0140-6736(88)91893-4

PMID:2896909

Abstract

A virus was isolated from the peripheral blood lymphocytes of patients with exanthem subitum, cultured successfully in cord blood lymphocytes, and shown to be antigenically related to human herpesvirus-6 (HHV-6). Morphological features, as studied by thin-section electronmicroscopy, resembled those of herpes group viruses. Convalescent-phase serum samples, tested against the new viral antigen and HHV-6 antigen, showed seroconversion. The results strongly suggest that the newly isolated virus is identical or closely related to HHV-6 and the causal agent for exanthem subitum.

摘要

从幼儿急疹患者的外周血淋巴细胞中分离出一种病毒，该病毒在脐血淋巴细胞中成功培养，并显示与人类疱疹病毒6型（HHV - 6）存在抗原相关性。通过超薄切片电子显微镜研究的形态学特征类似于疱疹病毒组病毒。用新病毒抗原和HHV - 6抗原检测恢复期血清样本，显示有血清转化。结果强烈表明，新分离出的病毒与HHV - 6相同或密切相关，是幼儿急疹的病原体。