Tanaka K, Kondo T, Torigoe S, Okada S, Mukai T, Yamanishi K
Department of Pediatrics, Osaka University Medical School, Japan.
J Pediatr. 1994 Jul;125(1):1-5. doi: 10.1016/s0022-3476(94)70113-x.
Human herpesvirus 7 (HHV-7) was isolated from peripheral blood mononuclear cells of two infants with typical exanthem subitum. The HindIII-, BamHI-, and EcoRI-digested DNA patterns of the isolated viruses were very similar to that of the prototype HHV-7 (RK strain), but different from that of human herpesvirus 6 (HHV-6). During the convalescent period of the first patient, the titer of antibody to HHV-7 rose from < 1:10 to 1:320 by an immunofluorescence antibody test, whereas the titer of antibody to HHV-6 remained < 1:10. In the second patient, who had two independent episodes of exanthem subitum during 2 months, both HHV-6 and HHV-7 were sequentially isolated; seroconversion to HHV-6 occurred during the first episode and to HHV-7 during the second episode. In addition, sera from another 15 children who had episodes of exanthem subitum were serologically tested for antibodies to HHV-6 and HHV-7 by immunofluorescence antibody test. Five of seven patients had seroconversion to HHV-7 just after having typical signs and symptoms of exanthem subitum. These results suggest that HHV-7 is one of the causative agents of exanthem subitum.
从两名患有典型幼儿急疹的婴儿外周血单个核细胞中分离出人类疱疹病毒7（HHV-7）。分离出的病毒经HindIII、BamHI和EcoRI酶切后的DNA图谱与HHV-7原型（RK株）非常相似，但与人类疱疹病毒6（HHV-6）不同。在首例患者的恢复期，通过免疫荧光抗体试验检测，其抗HHV-7抗体滴度从<1:10升至1:320，而抗HHV-6抗体滴度仍<1:10。在第二名患者中，其在2个月内出现了两次独立的幼儿急疹发作，先后分离出HHV-6和HHV-7；在首次发作时出现了针对HHV-6的血清转化，在第二次发作时出现了针对HHV-7的血清转化。此外，通过免疫荧光抗体试验对另外15名曾患幼儿急疹的儿童血清进行了HHV-6和HHV-7抗体的血清学检测。7名患者中有5名在出现典型的幼儿急疹体征和症状后不久就出现了针对HHV-7的血清转化。这些结果表明，HHV-7是幼儿急疹的病原体之一。
