Garg Sugandha, Kaur Amarjit, Mohi Jaswinder Kaur, Sibia Preet Kanwal, Kaur Navkiran
Junior Resident, Department of Radiology, Government Medical College and Rajindra Hospital, Patiala, Punjab, India.
Professor, Department of Radiology, Government Medical College and Rajindra Hospital, Patiala, Punjab, India.
J Clin Diagn Res. 2017 Aug;11(8):TC06-TC09. doi: 10.7860/JCDR/2017/26790.10353. Epub 2017 Aug 1.
IOTA stands for International Ovarian Tumour Analysis group. Ovarian cancer is one of the common cancers in women and is diagnosed at later stage in majority. The limiting factor for early diagnosis is lack of standardized terms and procedures in gynaecological sonography. Introduction of IOTA rules has provided some consistency in defining morphological features of ovarian masses through a standardized examination technique.
To evaluate the efficacy of IOTA simple ultrasound rules in distinguishing benign and malignant ovarian tumours and establishing their use as a tool in early diagnosis of ovarian malignancy.
A hospital based case control prospective study was conducted. Patients with suspected ovarian pathology were evaluated using IOTA ultrasound rules and designated as benign or malignant. Findings were correlated with histopathological findings. Collected data was statistically analysed using chi-square test and kappa statistical method.
Out of initial 55 patients, 50 patients were included in the final analysis who underwent surgery. IOTA simple rules were applicable in 45 out of these 50 patients (90%). The sensitivity for the detection of malignancy in cases where IOTA simple rules were applicable was 91.66% and the specificity was 84.84%. Accuracy was 86.66%. Classifying inconclusive cases as malignant, the sensitivity and specificity was 93% and 80% respectively. High level of agreement was found between USG and histopathological diagnosis with Kappa value as 0.323.
IOTA simple ultrasound rules were highly sensitive and specific in predicting ovarian malignancy preoperatively yet being reproducible, easy to train and use.
IOTA代表国际卵巢肿瘤分析小组。卵巢癌是女性常见癌症之一，大多数患者在疾病晚期才被诊断出来。妇科超声检查缺乏标准化术语和程序是早期诊断的限制因素。IOTA规则的引入通过标准化检查技术，在定义卵巢肿块的形态特征方面提供了一定的一致性。
评估IOTA简单超声规则在鉴别卵巢良恶性肿瘤以及将其用作卵巢恶性肿瘤早期诊断工具方面的有效性。
开展了一项基于医院的病例对照前瞻性研究。对疑似卵巢病变的患者使用IOTA超声规则进行评估，并确定为良性或恶性。将检查结果与组织病理学结果进行对比。使用卡方检验和kappa统计方法对收集的数据进行统计分析。
最初的55例患者中，最终纳入50例接受手术的患者进行分析。这50例患者中有45例（90%）适用IOTA简单规则。在适用IOTA简单规则的病例中，检测恶性肿瘤的敏感性为91.66%，特异性为84.84%。准确率为86.66%。将不确定病例分类为恶性时，敏感性和特异性分别为93%和80%。超声检查与组织病理学诊断之间存在高度一致性，kappa值为0.323。
IOTA简单超声规则在术前预测卵巢恶性肿瘤方面具有高度敏感性和特异性，且具有可重复性、易于培训和使用。
