Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University Jena , Humboldtstraße 8, D-07743 Jena, Germany.
INNOVENT e.V. Technologieentwicklung Jena , Prüssingstraße 27 B, D-07745 Jena, Germany.
J Am Chem Soc. 2017 Nov 1;139(43):15292-15295. doi: 10.1021/jacs.7b07427. Epub 2017 Oct 9.
Applicability of phototherapeutic CO-releasing molecules (photoCORMs) is limited because they are activated by harmful and poorly tissue-penetrating near-ultraviolet light. Here, a strategy is demonstrated to activate classical photoCORM Mn(CO) using red light (635 nm). By mixing in solution a triplet photosensitizer (PS) with the photoCORM and shining red light, energy transfer occurs from triplet excited-state PS* to a photolabile triplet state of Mn(CO), which, like under near-UV irradiation, led to complete release of carbonyls. Crucially, such "triplet-sensitized CO-release" occurred in solid-state materials: when PS and Mn(CO) were embedded in electrospun nonwoven fabrics, CO was liberated upon irradiation with low-intensity red light (≤36 mW 635 nm).
光疗 CO 释放分子（photoCORMs）的适用性有限，因为它们需要有害且穿透力差的近紫外光才能激活。在这里，展示了一种使用红光（635nm）激活经典 photoCORM Mn(CO)的策略。通过将三重态光敏剂（PS）与 photoCORM 在溶液中混合并照射红光，能量从三重态激发态 PS*转移到 Mn(CO)的光不稳定三重态，这与在近紫外光下一样，导致完全释放羰基。至关重要的是，这种“三重态敏化 CO 释放”发生在固态材料中：当 PS 和 Mn(CO)嵌入静电纺非织造织物中时，在低强度红光（≤36mW 635nm）照射下会释放 CO。
