Ramu Vadde, Upendar Reddy Gandra, Liu Jingjing, Hoffmann Patrick, Sollapur Rudrakant, Wyrwa Ralf, Kupfer Stephan, Spielmann Christian, Bonnet Sylvestre, Neugebauer Ute, Schiller Alexander
Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena, Humboldtstr. 8, 07743, Jena, Germany.
Center for Sepsis Control and Care (CSCC), Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.
Chemistry. 2019 Jun 26;25(36):8453-8458. doi: 10.1002/chem.201901396. Epub 2019 May 20.
Phototherapeutic applications of carbon monoxide (CO)-releasing molecules are limited because they require harmful UV and blue light for activation. We describe two-photon excitation with NIR light (800 nm)-induced CO-release from two Mn tricarbonyl complexes bearing 1,8-naphthalimide units (1, 2). Complex 2 behaves as a logic OR gate in solution, nonwovens, and in HeLa cells. CO release, indicated by fluorescence enhancement, was detected in solution, nonwoven, and HeLa cells by single- (405 nm) and two-photon (800 nm) excitation. The photophysical properties of 1 and 2 have been measured and supported by DFT and TDDFT quantum chemical calculations. Both photoCORMs are stable in the dark in solution and noncytotoxic, leading to promising applications as phototherapeutics with NIR light.
一氧化碳（CO）释放分子的光疗应用受到限制，因为它们需要有害的紫外线和蓝光来激活。我们描述了用近红外光（800 nm）进行双光子激发诱导带有1,8-萘二甲酰亚胺单元的两种锰三羰基配合物（1、2）释放CO。配合物2在溶液、非织造布和HeLa细胞中表现为逻辑或门。通过单光子（405 nm）和双光子（800 nm）激发，在溶液、非织造布和HeLa细胞中检测到由荧光增强指示的CO释放。已测量了1和2的光物理性质，并通过密度泛函理论（DFT）和含时密度泛函理论（TDDFT）量子化学计算得到支持。两种光控一氧化碳释放分子（photoCORMs）在溶液中黑暗条件下稳定且无细胞毒性，有望作为近红外光光疗剂得到应用。
