Idrees Syed Muhammad, Khan Majid, Humayun Mohammad, Khan Wazir Muhammad, Anwar Muhammad Syed, Naveed Sadaf
Department of Medicine, Khyber Teaching Hospital, Peshawar, Pakistan.
Department of Radiology, Khyber Teaching Hospital, Peshawar, Pakistan.
J Coll Physicians Surg Pak. 2017 Sep;27(9):S80-S81.
Hypovitaminosis D is an under-recongnised and important factor responsible for secondary hyperparathyroidism. Hyperparathyroidism mostly presents with osteolytic lesions, especially in secondary hyperparathyroidism with renal failure. There are some rare presentations of hyperparathyroidism as focal or generalized osteosclerotic lesions. The exact mechanism for the osteosclerosis is still unknown, but there are some theories suggesting an exaggerated response of osteoblasts in response to prolonged osteolytic activity in order to restore bone loss. Here, we report a case of secondary hyperparathyroidism secondary to severe Vitamin D deficiency presented as multiple osteosclerotic lesions.
维生素D缺乏是导致继发性甲状旁腺功能亢进的一个未得到充分认识的重要因素。甲状旁腺功能亢进大多表现为溶骨性病变，尤其是在肾衰竭所致的继发性甲状旁腺功能亢进中。甲状旁腺功能亢进还有一些罕见的表现形式，如局灶性或全身性骨硬化性病变。骨硬化的确切机制尚不清楚，但有一些理论认为，成骨细胞为了修复骨质流失，对长期的溶骨活动做出了过度反应。在此，我们报告一例因严重维生素D缺乏继发的继发性甲状旁腺功能亢进，表现为多发骨硬化性病变。
