Khokhar Nasir, Nasir Humaira, Amir Mohammad, Hassan Saira, Khan Khushal, Ahmed Mobeen
Departments of Gastroenterology and Hepatology, Shifa International Hospital and Shifa Tameer-e-Millat University, Islamabad.
Departments of Pathology, Shifa International Hospital and Shifa Tameer-e-Millat University, Islamabad.
J Coll Physicians Surg Pak. 2017 Sep;27(9):S114-S116.
Lymphoepithelioma-like carcinoma of esophagus is a rare tumor with about 20 cases reported worldwide. It can involve the salivary gland, esophagus, stomach, thymus, thyroid, breast, lung, uterus, cervix, urinary bladder, and the skin. Its association with Epstein Barr virus has been postulated. We report the case of a 45-year female who had been treated for hepatitis C and esophageal tuberculosis and recovered fully from these conditions. She presented with dysphagia of 2-3 month duration. Endoscopic examination revealed narrowing of the esophageal lumen with a fungating mass at the lower end of esophagus with no extension into the stomach. ACTscan confirmed a mass at the lower end of esophagus with multiple enlarged mediastinal lymph nodes. Histological and immunohistochemistry of esophageal biopsy sample showed lymphoepithelioma-like carcinoma. She was managed with chemotherapy comprising of capecitabine, epirubicin and cisplatin followed by esophagectomy and made full recovery.
食管淋巴上皮瘤样癌是一种罕见肿瘤,全球报道约20例。它可累及唾液腺、食管、胃、胸腺、甲状腺、乳腺、肺、子宫、宫颈、膀胱及皮肤。已推测其与爱泼斯坦-巴尔病毒有关。我们报告一例45岁女性病例,该患者曾接受丙型肝炎和食管结核治疗并完全康复。她出现了持续2至3个月的吞咽困难。内镜检查显示食管腔狭窄,食管下端有一蕈伞状肿物,未累及胃。CT扫描证实食管下端有肿物,伴有多个纵隔淋巴结肿大。食管活检样本的组织学和免疫组化检查显示为淋巴上皮瘤样癌。她接受了由卡培他滨、表柔比星和顺铂组成的化疗,随后进行了食管切除术,并完全康复。