Micevych Paul E, Mermelstein Paul G, Sinchak Kevin
Department of Neurobiology, David Geffen School of Medicine at the University of California Los Angeles (UCLA), and Laboratory of Neuroendocrinology of the UCLA Brain Research Institute, Los Angeles, CA 90095, USA.
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Trends Neurosci. 2017 Nov;40(11):654-666. doi: 10.1016/j.tins.2017.09.001. Epub 2017 Sep 29.
Over the past few years our understanding of estrogen signaling in the brain has expanded rapidly. Estrogens are synthesized in the periphery and in the brain, acting on multiple receptors to regulate gene transcription, neural function, and behavior. Various estrogen-sensitive signaling pathways often operate in concert within the same cell, increasing the complexity of the system. In females, estrogen concentrations fluctuate over the estrous/menstrual cycle, dynamically modulating estrogen receptor (ER) expression, activity, and trafficking. These dynamic changes influence multiple behaviors but are particularly important for reproduction. Using the female rodent model, we review our current understanding of estradiol signaling in the regulation of sexual receptivity.
在过去几年里，我们对大脑中雌激素信号传导的理解迅速扩展。雌激素在外周和大脑中合成，作用于多种受体以调节基因转录、神经功能和行为。各种雌激素敏感信号通路通常在同一细胞内协同运作，增加了系统的复杂性。在雌性动物中，雌激素浓度在发情周期/月经周期中波动，动态调节雌激素受体（ER）的表达、活性和运输。这些动态变化影响多种行为，但对生殖尤为重要。我们使用雌性啮齿动物模型，回顾了目前对雌二醇信号传导在性接受调节方面的理解。
