Kim Su Mi, An Ji Yeong, Choi Min-Gew, Lee Jun Ho, Sohn Tae Sung, Kim Kyung-Mee, Kim Sung, Bae Jae Moon
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Gastric Cancer. 2017 Sep;17(3):277-281. doi: 10.5230/jgc.2017.17.e22. Epub 2017 Jul 25.
Plexiform angiomyxoid myofibroblastic tumor (PAMT) of the stomach is a very rare mesenchymal tumor of the gastrointestinal tract. We report a case of asymptomatic gastric PAMT that was pathologically confirmed after surgical resection. The tumor had a multinodular plexiform growth pattern, bland-looking spindle cells, and an Alcian blue-positive myxoid stromal matrix rich in small blood vessels. Immunohistochemistry analysis revealed that the tumor cells of the PAMT were positive for smooth muscle actin (SMA) and negative for c-kit, CD34, S-100 protein, epithelial membrane antigen (EMA), and desmin. PAMT should be differentiated from other submucosal tumors of the stomach by immunohistochemical findings. Considering the benign features of this tumor, observation without resection may be an option for the treatment of PAMT if the tumor is asymptomatic.
胃丛状血管黏液样肌成纤维细胞瘤（PAMT）是一种非常罕见的胃肠道间叶肿瘤。我们报告一例无症状的胃PAMT病例，经手术切除后病理确诊。肿瘤呈多结节丛状生长模式，梭形细胞形态温和，阿利新蓝阳性的黏液样间质基质富含小血管。免疫组化分析显示，PAMT的肿瘤细胞平滑肌肌动蛋白（SMA）呈阳性，而c-kit、CD34、S-100蛋白、上皮膜抗原（EMA）和结蛋白呈阴性。应通过免疫组化结果将PAMT与胃的其他黏膜下肿瘤相鉴别。鉴于该肿瘤的良性特征，如果肿瘤无症状，观察而非切除可能是PAMT的一种治疗选择。
