Center for Dental Medicine, Department of Operative Dentistry and Periodontology, University Freiburg Medical Center, Freiburg, Germany.
Private Dental Practice, Dres. Kuerschner & Kuerschner, Friedrichshafen, Germany.
Clin Oral Investig. 2018 Apr;22(3):1263-1271. doi: 10.1007/s00784-017-2209-9. Epub 2017 Oct 2.
The objective of this study was to investigate clinical and microbiological gingival changes during pregnancy in women without periodontal disease. Additionally, these parameters were to be compared in women with high risk for preterm birth and women with a normal course of pregnancy.
Group I consisted of 40 subjects at high risk for preterm birth, while group II involved 49 subjects with a normal course of pregnancy. The control group (III) was made up of 50 non-pregnant women. Clinical parameters (plaque index, gingival index, probing pocket depths, gingival swelling, bleeding on probing) and microbiological changes were monitored during pregnancy and 2-4 weeks after parturition.
In the high-risk preterm group (I), 19 women could be included in data analysis. This group was compared to 41 women in the normal pregnancy group (II) and 50 non-pregnant women (III). Gingival inflammation was significantly higher in women with high risk for preterm birth (I) compared to non-risk pregnant women (II, p < 0.05). In addition, in this group (I), the subgingival amounts of Fusobacterium nucleatum (> 10) were found to be significantly higher after childbirth compared to non-pregnant women (p < 0.05).
Even without having periodontal disease, women with high risk for preterm birth showed worse clinical values compared to non-risk pregnant and non-pregnant women and an increased detection of Fusobacterium nucleatum after delivery.
High risk for preterm birth might be associated with the occurrence of increased gingival inflammation.
本研究旨在探讨无牙周病的孕妇在怀孕期间的临床和微生物学牙龈变化，并比较早产高危孕妇和正常妊娠孕妇的这些参数。
第 I 组包括 40 名早产高危孕妇，第 II 组包括 49 名正常妊娠孕妇。对照组（III）由 50 名非孕妇组成。在怀孕期间和分娩后 2-4 周监测临床参数（菌斑指数、牙龈指数、探诊牙周袋深度、牙龈肿胀、探诊出血）和微生物学变化。
在早产高危组（I）中，有 19 名妇女可纳入数据分析。将该组与正常妊娠组（II）的 41 名妇女和 50 名非孕妇（III）进行比较。与非高危孕妇（II）相比，早产高危孕妇（I）的牙龈炎症明显更高（p<0.05）。此外，在该组（I）中，分娩后龈下数量 Fusobacterium nucleatum（>10）的检出明显高于非孕妇（p<0.05）。
即使没有牙周病，早产高危孕妇的临床值也比非高危孕妇和非孕妇差，分娩后 Fusobacterium nucleatum 的检出率增加。
早产高危可能与牙龈炎症增加有关。
