裂叶荨麻叶的化学成分。
The chemical constituents from Urtica fissa leaves.
作者信息
Wang Meng-Yue, Yang Yan, Zhou Xi-Yan, Wang Shang-Shang, Duan Shi-Xin, Li Xiao-Bo
机构信息
a School of Pharmacy , Shanghai Jiao Tong University , Shanghai 200240 , China.
出版信息
J Asian Nat Prod Res. 2018 Aug;20(8):709-718. doi: 10.1080/10286020.2017.1383397. Epub 2017 Oct 3.
A new ceramide urticamide (1), two new secolignans urticalactones I (2) and Ⅱ (3), and a new flavonoid glycoside urticaside (4), together with 15 known compounds (4-19), were isolated from the leaves of Urtica fissa, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1, 2, 3, 8, and 13 possessed the potent anti-inflammatory. They could inhibit the release of NO and TNF-α in lipopolysaccharide (LPS) stimulated RAW 264.7 cells, with IC values less than 4.0 μM.
从中国民间用于治疗风湿性关节炎的植物裂叶荨麻的叶子中，分离得到了一种新的神经酰胺类化合物荨麻酰胺（1）、两种新的裂环木脂素类化合物荨麻内酯Ⅰ（2）和Ⅱ（3）、一种新的黄酮苷类化合物荨麻苷（4），以及15种已知化合物（5 - 19）。活性评价结果表明，化合物1、2、3、8和13具有较强的抗炎活性。它们能够抑制脂多糖（LPS）刺激的RAW 264.7细胞中一氧化氮（NO）和肿瘤坏死因子-α（TNF-α）的释放，半数抑制浓度（IC）值小于4.0 μM。
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