From the Department of Biology, Washington University, St. Louis, Missouri 63130 and.
the Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
J Biol Chem. 2018 Apr 6;293(14):5044-5052. doi: 10.1074/jbc.R117.815886. Epub 2017 Oct 2.
Cyanobacteria are photosynthetic prokaryotes showing great promise as biocatalysts for the direct conversion of CO into fuels, chemicals, and other value-added products. Introduction of just a few heterologous genes can endow cyanobacteria with the ability to transform specific central metabolites into many end products. Recent engineering efforts have centered around harnessing the potential of these microbial biofactories for sustainable production of chemicals conventionally produced from fossil fuels. Here, we present an overview of the unique chemistry that cyanobacteria have been co-opted to perform. We highlight key lessons learned from these engineering efforts and discuss advantages and disadvantages of various approaches.
蓝藻是光合原核生物，作为将 CO 直接转化为燃料、化学品和其他增值产品的生物催化剂具有巨大的应用潜力。只需引入少数几个异源基因，就可以使蓝藻具有将特定的中心代谢物转化为许多终产物的能力。最近的工程努力主要集中在利用这些微生物生物工厂的潜力，以可持续的方式生产传统上从化石燃料中获得的化学品。在这里，我们概述了蓝藻被用于执行的独特化学过程。我们强调了从这些工程努力中获得的关键经验教训，并讨论了各种方法的优缺点。
