Ni Jun, Tao Fei, Xu Ping, Yang Chen
State Key Laboratory of Microbial Metabolism, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
CAS-Key Laboratory of Synthetic Biology, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Adv Exp Med Biol. 2018;1080:239-259. doi: 10.1007/978-981-13-0854-3_10.
Recent years have witnessed a rising demand for bioproduced chemicals owing to restricted availability of petrochemical resources and increasing environmental concerns. Extensive efforts have been invested in the metabolic engineering of microorganisms for biosynthesis of chemicals and fuels. Among these, direct conversion of CO to chemicals by photoautotrophic microorganism cyanobacteria represents a green route with incredibly potent. Cyanobacteria have been engineered for the production of numerous biofuels and chemicals, such as 2,3-butanediol, fatty acids, isobutyraldehyde, and n-butanol. Under the current condition, it might be initially wiser to produce chemicals with higher value or higher yield. Photosynthetic production of C3 platform chemicals could withdraw carbon close to fixation to maximize the pool of available carbon, thus achieving the strong production rates. Photosynthetic production of terpenoids is another good choice due to the higher value of these compounds. Here, we review recent advances in generating C3 chemicals and valuable terpenoids from cyanobacteria.
近年来，由于石化资源的供应受限以及环境问题日益受到关注，生物生产化学品的需求不断上升。人们已在微生物代谢工程方面投入大量努力，用于化学品和燃料的生物合成。其中，光合自养微生物蓝细菌将CO直接转化为化学品代表了一条极具潜力的绿色途径。蓝细菌已被改造用于生产多种生物燃料和化学品，如2,3-丁二醇、脂肪酸、异丁醛和正丁醇。在当前条件下，最初生产具有更高价值或更高产量的化学品可能更为明智。光合生产C3平台化学品可以接近碳固定的方式提取碳，以最大化可用碳库，从而实现较高的生产率。由于萜类化合物价值更高，光合生产萜类化合物是另一个不错的选择。在此，我们综述了利用蓝细菌生产C3化学品和有价值萜类化合物的最新进展。
