Fodil M, Nghiem D, Colas M, Bourry S, Poisson-Salomon A-S, Rezigue H, Trivalle C
Christophe Trivalle, Service de Gérontologie 1, Hôpital Paul Brousse, 14 avenue Paul Vaillant-Couturier, F-94800, Villejuif, France. E-mail:
J Nutr Health Aging. 2017;21(8):904-908. doi: 10.1007/s12603-017-0886-3.
To assess the modification of the form of medication and evaluate staff observance of good clinical practices.
One-day assessment of clinical practices.
17 geriatrics units in the 3 Teaching Hospitals of Paris-Sud (APHP), France.
Elderly in-patients with difficulties swallowing capsules and tablets.
Assessment of target-patient prescriptions and direct observation of nurses' medical rounds.
155/526 in-patients (29.5%) were unable to swallow tablets or capsules: 98 (40.3%) in long-term care, 46 patients (23.8%) in the rehabilitation unit and 11 (12.2%) in the acute care unit (p = .005). In thirty-nine (27.3%) of the 143 prescriptions studied all tablets were safe to crush and all capsules were safe to open. In 104 cases, at least one medication could not be safely modified, including 26 cases (18.2%) in which none of the prescribed drugs were safe to crush or open. In 48.2% of the 110 medications that were crushed, crushing was forbidden, and presented a potential threat in 12.7% of cases or a reduced efficacy in 8.2% of cases. Crushing methods were rarely appropriate: no specific protective equipment was used (81.8%), crushing equipment was shared between patients without cleaning (95.1%), medications were spilled or lost (69.9%). The method of administration was appropriate (water, jellified water) in 25% of the cases, questionable (soup, coffee, compote, juice, cream) in 55% of the cases and unacceptable (laxative) in 21% of the cases.
Management of drug prescriptions in patients with swallowing difficulties is not optimal, and may even have iatrogenic effects. In this study, 12.7% of the modifications of the drug form could have been harmful. Doctors, pharmacists and nurses need to reevaluate their practices.
评估药物剂型的调整情况,并评价工作人员对良好临床实践的遵守情况。
对临床实践进行为期一天的评估。
法国巴黎南部3家教学医院(APHP)的17个老年病科。
吞咽胶囊和片剂有困难的老年住院患者。
评估目标患者的处方,并直接观察护士的查房情况。
155/526名住院患者(29.5%)无法吞咽片剂或胶囊:长期护理病房中有98名(40.3%),康复病房中有46名患者(23.8%),急性护理病房中有11名(12.2%)(p = 0.005)。在研究的143份处方中,有39份(27.3%)所有片剂均可安全碾碎,所有胶囊均可安全打开。在104例中,至少有一种药物不能安全调整剂型,其中26例(18.2%)所有处方药物均不能安全碾碎或打开。在碾碎的110种药物中,48.2%的碾碎操作是被禁止的,12.7%的情况存在潜在威胁,8.2%的情况疗效降低。碾碎方法很少恰当:未使用特定防护设备(81.8%),碾碎设备在患者间共用且未清洁(95.1%),药物洒出或丢失(69.9%)。给药方法在25%的情况下恰当(用水、凝胶水),55%的情况下有问题(用汤、咖啡、果脯、果汁、奶油),21%的情况下不可接受(用泻药)。
吞咽困难患者的药物处方管理并不理想,甚至可能产生医源性影响。在本研究中,12.7%的药物剂型调整可能有害。医生、药剂师和护士需要重新评估他们的做法。