巴西联邦区开展疫苗接种运动后孕妇的风疹血清阳性情况。

Rubella Seropositivity in Pregnant Women After Vaccination Campaign in Brazil's Federal District.

作者信息

Nóbrega Yanna K M, de Carvalho Bruna C, Nitz Nadjar, Vital Tamires E, Leite Franco B, Sequeira Inês J, Moreira Elsa E, de Andrade Juliana K B, Gandolfi Lenora, Pratesi Riccardo, Hecht Mariana M

机构信息

1 Immunogenetic and Chronic-Degenerative Diseases Laboratory, School of Medicine, University of Brasilia , Brasilia, Brazil .

2 Methodologies Applied to Infectious Diseases Laboratory, School of Medicine, University of Brasilia , Brasilia, Brazil .

出版信息

Viral Immunol. 2017 Nov;30(9):675-677. doi: 10.1089/vim.2017.0012. Epub 2017 Oct 3.

DOI:10.1089/vim.2017.0012

PMID:28972455

Abstract

Rubella is an acute viral disease that usually does not generate sequels; however, in pregnant women the infection can cause serious abnormalities to fetuses, which are collectively called congenital rubella syndrome. In Brazil, population immunization was started in 1992, but few epidemiological studies have been conducted to assess vaccination coverage and seroconversion since then. The aim of this work is to evaluate the seropositivity of pregnant women to rubella virus after vaccination campaign was carried out in 2008. Serological tests for rubella diagnosis were performed in 87 pregnant women who attended the University of Brasilia Hospital, Federal District, Brazil. Antirubella IgG antibodies were detected in 83 out of 87 pregnant women (95.4%), with an age-independent seroprevalence. Only one woman was positive in IgM serological tests. Our data suggest high levels of vaccination coverage and antirubella immunization in the Brazil Federal District population.

摘要

风疹是一种通常不会产生后遗症的急性病毒性疾病；然而，对于孕妇来说，这种感染会导致胎儿出现严重异常，这些异常统称为先天性风疹综合征。在巴西，1992年开始实施全民免疫，但自那时起，很少有流行病学研究来评估疫苗接种覆盖率和血清转化情况。这项工作的目的是评估2008年开展疫苗接种运动后孕妇对风疹病毒的血清阳性率。对巴西联邦区巴西利亚大学医院就诊的87名孕妇进行了风疹诊断的血清学检测。87名孕妇中有83名检测到抗风疹IgG抗体（95.4%），血清阳性率与年龄无关。只有一名女性IgM血清学检测呈阳性。我们的数据表明巴西联邦区人群的疫苗接种覆盖率和抗风疹免疫水平较高。